QT interval prolongation and torsades de pointes with oxaliplatin

Oxaliplatin is a platinum-containing antineoplastic agent that is used in the treatment of gastrointestinal cancers [Stein and Arnold, 2012; Alcindor and Beauger, 2011]. It is one of the most important treatments for colorectal cancer, and is commonly used in combination therapy with other cytotoxic drugs [Stein and Arnold, 2012; Alcindor and Beauger, 2011]. It may have survival benefits and better tolerability than cisplatin for advanced unresectable gastric cancer [Montagnani et al. 2011]. Oxaliplatin may also be an alternative treatment for patients with ovarian cancer, who have shown hypersensitivity to carboplatin [Bogliolo et al. 2015].