A Phase III study of radiation therapy (RT) and O6-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001

Deborah T. Blumenthal,Cathryn Rankin,Keith J. Stelzer,Alexander M. Spence,Andrew E. Sloan,Dennis F. Moore,Gilbert D. A. Padula,Susan Schulman,Mark Wade,Elisabeth J. Rushing

A Phase III study of radiation therapy (RT) and O6-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma: Southwest Oncology Group (SWOG) study S0001

2015

Deborah T. Blumenthal
Cathryn Rankin
Keith J. Stelzer
Alexander M. Spence
Andrew E. Sloan
Dennis F. Moore
Gilbert D. A. Padula
Susan Schulman
Mark Wade
Elisabeth J. Rushing

Aims To determine the efficacy of methylguanine methyltransferase (MGMT) depletion + BCNU [1,3-bis(2-chloroethyl)-1- nitrosourea: carmustine] therapy and the impact of methylation status in adults with glioblastoma multiforme (GBM) and gliosarcoma.

Keywords:

O6-Benzylguanine
Methylation
Gliosarcoma
DNA methylation
Nitrosourea
Radiation therapy
Carmustine
Oncology
Methyltransferase
Internal medicine
Medicine
Surgical oncology

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