COMPARISON OF SINGLE DOSE OF OMEPERPRAZOLE (20MG) VERSUS ESOMEPRAZOLE (40MG) ON GASTRIC ACIDITY

Objective: The objective of this study was to evaluate and compare the effectiveness of single dose of omeprazole 20mg and esomeprazole 40mg on stomach pH. Material and Methods: In this study 50 patients, of ASA class p 1 and p 2 status, of age 15 to 60 years and body mass index (BMI) 20 to 35 kg/m 2 undergoing inguinal hernia surgery electively of both sexes were included. In group “O” 20 mg Omeprazole and in group “E” 40 mg Esomeprazole was given to all participants on the night before surgery at 10 pm and were asked to remain nothing per orum after midnight. In morning after induction of general anaesthesia a multiorifice nasogastric tube (16F) was passed in stomach and verified by auscultation over epigastrium with 10ml air. Gastric fluid was withdrawn in a sterile syringe and transferred to a sterile test tube. pH was determined by calibrated pH paper and was confirmed by pH meter. Nasogastric tube was then removed. Results: In group “O” the median range of gastric fluid pH was 4.5 (1.5 – 7.0). In group “E” it was 7.0 (3.0 – 8.0). P value not significant. Conclusion: Single oral dose of Esomeprazole 40 mg at bed time before surgery has same efficacy in increasing the intragastric pH like single oral dose of Omeprazole 20 mg.