Abstract 17916: Effect of Spatial and Temporal Resolution on the Calculation of Global Longitudinal Strain by Three-Dimensional Echocardiography

Background: Global longitudinal strain by three-dimensional speckle tracking echocardiography (3D ECHO) is a sensitive marker of left ventricular (LV) mechanical dysfunction and correlates with diminshed ejection fraction (EF) by cardiac magnetic resonance imaging (CMR). However, calculation of global longitudinal strain by 3D ECHO can be performed in several ways, some of which maximize the spatial information obtained from the 3D dataset and some of which correct for the temporal dispersion of data. The objective of this study was to explore the effects of spatial and temporal dispersion of 3D data on the calculation of 3D global longitudinal strain in a mixed population of normal and heart failure subjects. Methods: 113 subjects (60% male) were prospectively studied. Of those, 69 were normal (Group 1), 16 had heart failure with preserved LV EF (Group 2) and 38 had heart failure with reduced LV EF (Group 3). Global longitudinal strain was derived by three methods: 1) by averaging the peak systolic value...