Carcinoma papilífero da tireoide associado à tireoidite de Hashimoto: frequência e aspectos histopatológicos

INTRODUCAO: O carcinoma papilifero e o tipo mais comum de câncer da tireoide e a tireoidite de Hashimoto e a causa mais frequente de hipotireoidismo em areas onde os niveis de iodo sao adequados. Varios investigadores detectaram incidencia aumentada de carcinoma papilifero da tireoide em pacientes com tireoidite de Hashimoto. Na rotina de diagnosticos histopatologicos ha uma aparente associacao entre as duas patologias. OBJETIVO: Determinar a relacao entre tireoidite de Hashimoto e carcinoma papilifero de tireoide, avaliando os aspectos histomorfologicos, quando concomitantes ou apresentando-se de forma isolada. METODO: Foi realizado estudo retrospectivo a partir dos dados do arquivo do Servico de Patologia do Hospital Barao de Lucena, afiliado ao Sistema Unico de Saude (SUS) (Recife-PE), incluindo 95 casos, entre 472 cirurgias de tireoide realizadas no periodo de janeiro de 1995 a janeiro de 2005. RESULTADOS: Houve 35 casos (7,4 por cento) de tireoidite de Hashimoto, 48 (10,2 por cento) de carcinoma papilifero e 12 (2,5 por cento) de associacao significativa (p INTRODUCTION: Papillary carcinoma is the most common type of thyroid cancer and Hashimoto's thyroiditis is the most frequent cause of hypothyroidism in areas where iodine levels are adequate. Several investigators have detected an increased incidence of papillary thyroid carcinoma in patients with Hashimoto's thyroiditis. In histopathological diagnosis routine, there is an apparent association between these two pathologies. OBJECTIVE: To determine the association between Hashimoto's thyroiditis and papillary thyroid carcinoma, evaluating the histopathological aspects, when concomitantly present or isolated. METHODS: A retrospective study was carried out with data from the archives of the Pathology Service at hospital Barao de Lucena, SUS (Recife-PE, Brazil), which included 95 cases amongst 472 thyroid surgeries performed from January 1995 through January 2005. RESULTS: There were 35 cases (7.4 percent) of Hashimoto's thyroiditis, 48 cases (10.2 percent) of papillary carcinoma and 12 cases (2.5 percent) of significant association of these pathologies (p