Compounds and compositions as modulators path Hedgehog

A compound of Formula I for use in a method of treatment of cancer by the modulation of Hedgehog signaling pathway: ** ** Formula wherein: Y1 and Y2 are independently selected from N and CH; R1 is selected from cyano, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted with halogen, alkoxy of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms substituted with halogen, dimethyl amino, alkyl of 1 to 6 carbon atoms and hetero-sulfanyl-cycloalkyl of 3 to 8 carbon atoms optionally substituted with up to 2 alkyl radicals of 1 to 6 carbon atoms; R2 and R5 are independently selected from hydrogen, cyano, halo, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted with halogen, alkoxy of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms carbon substituted by halogen, and dimethylamino; R3 and R4 are independently selected from hydrogen, halo, cyano, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted with halogen, alkoxy of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms carbon substituted by halogen; R6 and R7 are independently selected from hydrogen, methyl chloro, fluoro, bromo, trifluoromethyl and methoxy; with the proviso that R6 and R7 are not both hydrogen: and R8 is selected from hydrogen, chlorine and methyl trifluoromethyl; and R9 is selected from -S (O) 2R11, -C (O) R11, R11 and -NR12aR12b; wherein R11 is selected from thiomorpholino, sulfonomorfolino, sulfanomorfolino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2-oxopiperazin-1-yl, 1,4-oxazepan-4-yl, piperidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl and 1,4-diazepan-1-yl; R12a and R12b and is independently selected from isobutyl, hydroxyethyl, wherein said thiomorpholino, sulfonomorfolino, sulfanomorfolino, morpholino, cyclohexyl, phenyl, azepan-1-yl, 2- oxopiperazin-1-yl, 1,4-oxazepan-4 -yl, piperidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-yl, piperazinyl, pyrrolidinyl or R9 yl-1,4-diazepan-1 may be optionally substituted with 1 to 3 radicals independently selected from methyl, ethyl, methoxy, benzyl, thienyl-methyl and pyridinyl-methyl, benzo [d] [1,3] dioxol-6-yl and 2,3-diidrobenzo [b] [1,4] dioxin- 7-yl, wherein substituent said phenyl or benzyl R9 is optionally substituted with 1 to 3 radicals independently selected from methoxy, ethoxy, methyl-piperazyl, methyl, trifluoromethoxy, chloro, fluoro and trifluoromethyl, or a salt or an acceptable stereoisomer the same; wherein said cancer is selected from; pancreatic cancer, prostate cancer, breast cancer, medulloblastoma, basal cell carcinoma and small cell lung cancer.