Micropapillary predominance is a risk factor for brain metastasis in resected lung adenocarcinoma

Abstract Background Histologic subtyping can provide prognostic stratification in lung adenocarcinoma. We thus hypothesized that histologic subtypes may be useful for risk stratification of brain metastasis (BM). In this study, we aimed to investigate impact of histologic subtypes on risk for BM in patients with resected lung adenocarcinoma. Patients and Methods Of 1099 consecutive patients who had undergone curative-intent surgery (2000 to 2014), 448 patients who had undergone complete resection for lung adenocarcinoma were included in this study. Correlated clinical variables and BM-free survival were analyzed. Results Micropapillary predominance is significantly associated with higher risk of BM after complete resection in univariable (p Conclusion The current study demonstrated a significant correlation between micropapillary subtype and higher risk of BM in patients with resected lung adenocarcinoma. This routine histologic evaluation of resected adenocarcinoma may provide useful information for the clinician in considering postoperative management in patients with lung adenocarcinoma. Histologic subtyping which can provide prognostic stratification lung adenocarcinoma. Since brain metastasis is critical and often refractory to systemic chemotherapy, early detection is clinically important to perform effective local treatment. We retrospectively analyzed association between histologic subtypes and occurrence of brain metastasis. We found that significant association between micropapillary predominance and higher risk for brain metastasis. Our findings may be relevant in considering postoperative management. Mini-abstract Histologic subtyping which can provide prognostic stratification lung adenocarcinoma. Since brain metastasis is critical and often refractory to systemic chemotherapy, early detection is clinically important to perform effective local treatment. We retrospectively analyzed association between histologic subtypes and occurrence of brain metastasis. We found that significant association between micropapillary predominance and higher risk for brain metastasis. Our findings may be relevant in considering postoperative management.