Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant

S. Aubrey Stoch,Cynthia Gargano,Jack Valentine,Matthew P. Braun,M. Gail Murphy,Margaret Fedgchin,Anup Majumdar,Edward Pequignot,Keith M. Gottesdiener,Kevin J. Petty,Deborah Panebianco,Dennis C. Dean,Walter K. Kraft,Howard E. Greenberg

Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant

2011

S. Aubrey Stoch
Cynthia Gargano
Jack Valentine
Matthew P. Braun
M. Gail Murphy
Margaret Fedgchin
Anup Majumdar
Edward Pequignot
Keith M. Gottesdiener
Kevin J. Petty
Deborah Panebianco
Dennis C. Dean
Walter K. Kraft
Howard E. Greenberg

Purpose Because glucocorticoids and the neurokinin-1 receptor antagonist aprepitant influence CYP3A4 activity, this study assessed whether aprepitant added to a 5-HT3 antagonist and glucocorticoid would affect CYP3A4 induction.

Keywords:

Corticosteroid
Midazolam
Receptor antagonist
Aprepitant
Dexamethasone
Ondansetron
CYP3A4
Pharmacology
Glucocorticoid
Anesthesia
Medicine
Endocrinology
Crossover study
Internal medicine
Antagonist

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