Chirality manipulation of supramolecular self-assembly based on the host-guest chemistry of cyclodextrin

Abstract Chiral materials have been of the interests of scientists for nearly a century. People have endeavored a great effort to manipulate the chirality of various self-assembled materials. Among these efforts, cyclodextrins are employed only in recent years, although it has long been recognized that the chirality of cyclodextrin can be transferred to the guest. In this review, we for the first time to summarize the recent advancement of the supramolecular chirality manipulation on the basis of the host-guest chemistry of cyclodextrins. By utilizing the simple Harata-Kodaka’s rule, natural cyclodextrins can be exploited in a dynamic manner to create chirality inversion materials through crystalline self-assembly, which is facile and environment-friendly. What’s more, we also discussed the remarks on future outlooks at the end of this article and expect it to stimulate a rapid development on both theory and application level.