Maternal upper-body circumferences predict human milk adiponectin concentration (131.8)

Prenatal measures explain little of human milk adiponectin (HMA) variation. We examined whether postpartum metabolic and fat depot measures predict HMA from milk sampled concurrently. Participants underwent a morning oral glucose tolerance test, anthropometry (hip, iliac crest, waist, and under-breast circumferences; weight and BMI), and breast expression (N=20). Serum insulin, glucose, and total adiponectin were assayed, and insulin sensitivity and secretion were estimated. HMA was assayed using ELISA. Spearman rank coefficients and linear regression were used to examine relations with HMA. Serum adiponectin was the single significant metabolic correlate with HMA (r=0.45, p=0.048). HMA was not significantly correlated with BMI or weight, but became more negatively correlated with fat-depot specific anthropometry with increasing proximity to the breast: hip (r=-0.32, p=0.164); iliac crest (r=-0.46, p=0.039); waist (r=-0.50, p=0.025); under breast (r=-0.56, p=0.011). Combined, serum adiponectin and waist c...