Application of biological agents in children with rheumatic autoimmune disease

Biological agents has opened a new chapter in the targeted therapy of rheumatism,and provides a new choice for the rheumatism children who is refractory to traditional disease-modifying antirheumatic drugs.This article described the classification,application,efficency,side effects and precautions of the cytokines antagonists and the cell targeting biological agents,to provide a reference for rational application in clinical work. Key words: Biological agents;  Rheumatic autoimmune disease;  Juvenile idiopathic arthritis