Pharmacokinetics and pharmacodynamics analysis of drug candidates

Abstract Pharmacology deals with the activity of the drug in humans and the response of the body to the drug. Designing suitable drug molecules requires comprehensive prediction and analysis of the properties of drug candidates. Pharmacokinetics includes how the body absorbs, distributes, bio-transforms, and excretes drug molecules. Pharmacodynamics deals with the action of drug molecules at the site of action and its effect on the body. In the postgenomic era availability of genomic data of humans, pathogens are helping the designing of suitable drug candidate molecules by using computational and bioinformatics approaches. Pharmacokinetic and pharmacodynamic parameters are essential for the designing of potent drug, which is effective at minimum concentration with no or minimum side effect and must not give any toxic reaction. Computer-aided drug designing is becoming one of the most rapidly developing fields. During the postgenomics revolution period, the accessibility of genomic information about humans, pathogens, and plants is exponentially increasing. It became an urgent requirement to effectively store, manage, and retrieve the biological and chemical information for developing tools related to ADMET predictions.