Imaging findings of epilepsy on MRI and FDG-PET: Can partial volume effect correction improve focus detection on FDG-PET?

1231 Objectives The purpose of this exhibition is to review MRI and FDG-PET findings of diseases causing epilepsy and to discuss usefulness of partial volume effect (PVE) correction for improving focus detection on FDG-PET. Methods We selected epilepsy patients with the following brain disorders undergoing both MRI and FDG-PET: Focal cortical dysplasia, hemimegalencephaly, heterotopia, hippocampal sclerosis, ulegyria, ganglioglioma and dysembryoplastic neuroepithelial tumor. Although FDG-PET has been useful for diagnosis and management of epilepsy, PVE due to the low spatial resolution can make it dificult to detect the foci. To solve the problem, we tried to apply voxel-wise PVE correction to FDG-PET images with modified Muller-Gartner method using segmented and coregistered MRI. Results We demonstrated clinical features, MRI and FDG-PET findings, differential diagnosis and treatment progress of the above disorders. We also showed some cases in which PVE correction on FDG-PET helped to distinguish the true focus from artifacts due to PVE. Conclusions MRI and FDG-PET imagings play an essential role in localization of seizure foci and differential diagnosis. Therefore, the knowledge of neuroimaging findings is important for selecting the appropriate treatment, especially surgical treatment. Furthermore, PVE correction allows more precise focus detection on FDG-PET. RESEARCH SUPPORT: None