Hypolipidemic Activity of Phyllanthus Emblica Linn (Amla) & Trigonella Foenum Graecum (Fenugreek) Combination In Hypercholesterolemic Subjects – A Prospective, Randomised, Parallel, Open-Label, Positive Controlled Study
2012
The present study is aimed at to evaluate the hypolipidemic and antioxidant activity of combination
of fenugreek and amla in hyperlipidemic subjects.Twenty eight subjects were selected from outpatient
department of medicine with the inclusion criteria of total cholesterol > 220mg/dl and or serum triglyceride
>140mg/dl. They were enrolled for a period of 12 weeks after obtaining written informed consent. Subjects
were randomly divided into 2 groups. Group I [test drug combination -1000mg Amla + 500mg Fenugreek/day]
and Group II [standard drug Atorvastatin 10 mg daily]. Subjects were evaluated every 4 weeks for 12 weeks.
During these visits biochemical investigations of lipid profile and antioxidant activity were done. At the end of
12 weeks, there were significant decrease in serum total cholesterol (20-26%), LDL (25-34%), triglyceride (15-
30%) and VLDL (15-30%) levels & an increase in the HDL (0-5%) in the test drug group. This combination has
shown similar response on lipid profile as statins with lesser adverse effects. Antioxidant activity of the
combination is also demonstrated in the trial.
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