Tiopronin For treating Medicamentous Liver Injury Caused by Antituberculous Drugs

Objective To investigate the efficacy of tiopronin on treating medicamentous liver injury caused by antituberculous drugs.Method The patients were randomly assigned to two groups:61 cases were in the treatment group treated with tiopronin,and 60 cases in the control group treated with general liver protectant.Results There was no statistically difference between the treatment group and the control group before treatment(t=0.6073,P0.05);After 4 weeks of treatment,there were statisticall differences between the treatment group and the control group(t=3.9212,P0.05).The normalization rates of ALT and TBIL in the treatment group 78.69%,91.8% and 100% were better than that of the control group 36.67%,71.67% and 90.00%(χ2=16.83,P0.01),Conclusion Tiopronin shows obvious curative effect in the treatment of medicamentous liver injury caused by antituberculous drugs.