Diagnostic value of radionuclide in bone metastasis after breast cancer surgery: A protocol of systematic review.

Background The objective of this study is to evaluate the accuracy of radionuclide in diagnosis of bone metastasis (BM) after breast cancer surgery (BCS). Methods The electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CBM, and CNKI) will be systematically and comprehensively searched until June 1, 2020 for eligible studies that reported the diagnosis of radionuclide in BM after BCS. In addition, we will also identify grey literatures, such as conference abstracts, and reference lists of included studies. All process of study identification, data extraction, and study methodological quality evaluation will be performed by 2 independent authors. All divergences will be settled by a third author through discussion. All data analysis will be carried out by RevMan 5.3 software (London, UK). Results This study will scrutinize the most recent evidence of radionuclide in detection of BM after BCS. Conclusion This study may provide evidence of accuracy of radionuclide in diagnosis of BM following BCS. Study registration number PROSPERO CRD42020187646.