The Curative Effect of Ginkgo biloba Preparations on Hepatic Fibrosis in Rats Induced by Combined Factors

Objective: To investigate the therapeutic effect of Gingo biloba preparation in rat hepatic fibrosis induced by combined factors.Methods: Seventy male Wistar rats were divided into normal group,model group,naturally recovering group,and treament group randomly.All of the rats except those in normal group were influenced by combined inducing factors including CCL4,alcohol,and high fat/low protein food for 8 weeks to cause hepatic fibrosis.Then,the rats in treatment group were administered with Gingo biloba via stomach-tube-pouring for 8 weeks.Liver indexes,serum hyaluronic acid(HA),and hydroxyproline(Hyp) contents in liver tissue were measured,and the extent of the liver fibrosis was observed under light microscope.Results: Compared with rats in normal group,the liver indexes,HA and Hyp contents rose significantly(P0.05) in model group and naturally recovering group,while compared with rats in model group and recovering group,the liver indexes,HA,and Hyp contents of the treatment group fell significantly(P0.05).Conclusion: Gingo biloba has an anti-fibrogenic effect.