Abstract A88: Ancestry informative markers associated with prostate cancer in African Americans

Purpose: Prostate cancer (Pca) is the most common cancer in US males. African American men have higher incidence and mortality rates than do their European American counterparts. Five single nucleotide polymorphisms (SNPs) were found to be associated with Pca after analyzing data from a Pca mapping by admixture linkage disequilibrium (MALD) study using several different genetic models. The SNPs genotyped have significant allele frequency differences between African Americans and European Americans and are referred to as ancestry informative markers (AIMs). We tested the hypothesis that AIM haplotypes were also associated with Pca risk. Design Methods: AIM haplotypes were inferred for 98 Pca patients and 140 controls. Binary logistic regression was used to test haplotypes for association with Pca. Results: We found that haplotypes 5 “GTCCC,” 9 “ATTCT,” and 11 “ACCCC” were associated with Pca risk (OR = 3.97 95% CI: 1.68–9.47, p = 0.0017; OR = 7.17 95% CI: 2.33–20.05, p = 0.0006; OR = 3.68 95% CI: 1.57–8.62, p = 0.0027, respectively). After adjusting for age and ancestry all three haplotypes remained associated with Pca (OR = 3.62 95% CI: 1.42–9.21, p = 0.0070; OR = 7.89 95% CI: 2.36–26.31, p = 0.0008; OR = 4.34 95% CI: 1.75–10.78, p = 0.0016, respectively). We show that AIM haplotypes are associated with PCa risk. This study also demonstrates the use of a simple model to test for the additive or multiplicative effects of SNPs weakly associated individually. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):A88.