Observation on clinical curative effect of Monostalotetrahexosylgangliside on peripheral neuritis after chemotherapy

Objective To investigate the clinical efficacy of Monostalotetrahexosylgangliside (GM1) in treatment of peripheral neuritis after chemotherapy.Methods 172 cases of peripheral neuritis after chemotherapy were randomly divided into two groups.Treatment group with 86 cases was treated with GM1,40 mg,intravenous infusion,one time a day,until the end of chemotherapy.Control group with 86 patients was treated with vitamin B6 tablets 60 mg,orally,three times a day,until the end of chemotherapy.Two groups were assessed respectively for efficacy.Results The effect of treatment group (80.2 ％) was obviously better than that of control group (8.1％).The difference was statistically significant (P＜0.05).Conclusions GM1 can relieve peripheral neuritis of breast cancer patients after chemotherapy. Key words: Monostalotetrahexosylgangliside; Peripheral neuritis; Chemotherapy