Relative bioavailability and bioequivalence of the antimycotics ketoconazole and fluconazole

Abstract Pharmacokinetics and bioavailability of the antimycotics ketoconazole FPO and fluconazole (Russia) and the analogous drugs nizoral (Belgium) and diflucan (France) were comparatively studied on animals and in clinical trials. The pharmacokinetic parameters of the drugs were determined and their bioequivalence was shown (90-110%) that is evident of their therapeutic equality.