Characterization of aspirin-sensitivity in patients with asthma and chronic rhinosinusitis without a history of symptoms upon acetyl-salicylic acid (ASA) ingestion: a case series

Background Sensitivity to Non-steroidal Anti-inflammatory Drugs (NSAIDs) is a possible cause of exacerbations in patients with asthma. NSAID sensitivity associated to chronic rhinosinusitis with nasal polyps features Aspirin-Exacerbated Respiratory Disease (AERD). Patients with AERD generally require long-term treatment with inhaled corticosteroids for moderate to severe persistent asthma. Respiratory reactions may begin within minutes to hours after ingestion of NSAIDs.