Chances of Finding Matched Unrelated Donors for Saudi Patients in Need of Hematopoietic Stem Cell Transplantation

Abstract Background Finding HLA matched donors for patients in need of hematopoietic stem cell transplantation (HSCT), stands a better chance in their own ethnic group. This information led many nations to establish unrelated stem cell donor registries. We started our Saudi Stem Cell Donor registry (SSCDR) in 2011. The calculated donor pool size was nearly a million donors in order to find a matched donor for every patient. So far we have recruited 75,145 donors. Objective In this exercise we attempted to investigate the chances of finding a matched donor for Saudi patients in need of HSCT. Study Design A total of 445 patients were recruited for this study. Donor searches were carried out locally and internationally using Prometheus software and WMDA Search and Match Service respectively. Results Only 24% of the patients found a matched donor in our registry, 12% found a donor in other registries, making it a total of 36% of our patients have the chance to find a full 10/10 HLA matched donor. However, when we included 9/10 and 8/10 with the full matched donors, the chances go up to 83%. The top scoring registries for number of patients finding 10/10 matched donors were SSCDR (108), DE-ZKRD (52), SA-KFSHRC (52), US-NMDP (43), TR-URKOK (39), GB-DKMS (24), IL-Ezer Mizion (20). The patient that found the highest number of donors in international registries carried the European haplotype A1-B8-DR3, a total of 272 donors were found and none of them were from our registry. Patients with the highest matched donor numbers in SSCDR carried haplotypes that were not common in international registries. Conclusion Having a local registry increases the chances of finding a matched donor for our patients, however, international registries can still add to the chances of finding matched donors. Increasing our donor pool will increase chances of our patients finding a matched donor.