Mortality and survival rates in children and adolescents enrolled in early phase trials with a dose-finding/dose-confirmation component: An innovative therapies for children with cancer (ITCC) study.

Fernando Carceller,Francisco Bautista,Alicia Castañeda,Aurore Surun,Ajla Wasti,Gabriel Revon Rivière,Marta Cortés,Luca Bergamaschi,Antonio Juan Ribelles,Gerard Millen,Quentin Campbell-Hewson,Loredana Amoroso,Jasper Van der Lugt,Franca Fagioli,Michel Zwaan,Lynley V. Marshall,Gilles Vassal,Andrew D.J. Pearson,Birgit Geoerger,Lucas Moreno

Mortality and survival rates in children and adolescents enrolled in early phase trials with a dose-finding/dose-confirmation component: An innovative therapies for children with cancer (ITCC) study.

2019

e21509Background: Participation of children with advanced solid cancers in phase I trials raises ethical and logistic dilemmas. Life-expectancy beyond 8-12 weeks is a common inclusion criterion, bu...

Keywords:

Cancer
Pediatrics
Innovative Therapies
Physical therapy
Medicine
phase i trials
early phase
dose finding

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