Urinary excretion of albumin and beta-2-microglobulin in hypertensive and normotensive renal transplant recipients during urinary diluting and concentrating tests

Urinary excretion of albumin and beta-2-microglobulin was measured in nine hypertensive and nine normotensive renal transplant recipients and 10 healthy control subjects before and after an oral water load of 20 ml (kg body weight)−1 (study 1) and in eight hypertensive and 11 normotensive renal transplant recipients and 11 healthy control subjects during 24-h water deprivation (study 2). In both studies 1 and 2 urinary albumin excretion was significantly higher (p<0.01) in the hypertensive renal transplant recipients than in the normotensive patients and the control subjects (levels before loading: hypertensives: 23.9 μg/min(median), range 7.5-58.7; normotensives: 3.4 μg/min, range 1.0-49.3; controls: 2.9 μg/min, range 1.3-10.3). Urinary albumin excretion was significantly positive correlated to both systolic, diastolic and mean blood pressure (for mean blood pressure: rho=0.625, n = 18, p<0.01) in transplanted patients. Albumin excretion tended to increase after water loading and to decrease during water...