Management of pregnant women with COVID-19: A tertiary pandemic center experience on 1416 cases.

Objective To share the comprehensive experience of a tertiary pandemic center on pregnant women with COVID-19 and to compare clinical outcomes between pregnancy trimesters. Methods The present prospective cohort study consisted of pregnant women with COVID-19 who were followed up at Ankara City Hospital between 11.03.2020 and 20.02.2021. Clinical characteristics and perinatal outcomes were compared between the pregnancy trimesters. Results A total of 1416 pregnant women (1400 singletons and 16 twins) with COVID-19 were evaluated. 26 (1.8%) patients were admitted to intensive care unit (ICU) and maternal mortality was observed in 6 (0.4%) cases. Pregnancy complications were present in 227 (16.1%) cases and preterm labor was the most common one (n=42, 2.9%). There were 311, 433, and 672 patients in the first, second, and third trimesters of pregnancy, respectively. Rates of mild and severe/critic COVID-19 were highest in the first and second trimesters, respectively. The hospitalization rate was highest in the third trimester. Pregnancy complications, maternal mortality, and NICU admission rates were similar between the groups. Conclusion The course of the disease and obstetric outcomes may be different among pregnancy trimesters. The worse course of the disease may be observed even in pregnant women without any coexisting health problems. This article is protected by copyright. All rights reserved.