[Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured hypothalamic cells].

Aim: To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na +?K + currents. Methods: After hypoxic preconditioning and acute anoxia the I Na ?I K were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique. Results: The amplification of Na + currents did not been significantly changed,but the amplification of K + currents was increased in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na +?K + currents in the two groups,while Na +?K + currents in non-preconditioned control group were inhibited severelier than hypoxic preconditioning group. Conclusion: It is presumed that the enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K + channels.