In-vivo waveguide cardiac magnetic resonance elastography

Background Myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction(HFPEF)[1]. In addition, stiffness elevation in HFPEF exhibits directional dependency [2]. Conventional determinants of MS such as pressurevolume relationship and mechanical testing are invasive and hence clinically inefficient. Therefore, there is a need to non-invasively estimate anisotropic MS to assist in diagnosis and prognosis of HFPEF. In this study we implement waveguide cardiac magnetic resonance elastography (CMRE)[3] to demonstrate the feasibility of estimating anisotropic MS non-invasively in an in-vivo porcine model.