Chlordiazepoxide-fluoxetine interactions on food intake in free-feeding rats ☆

Abstract Chlordiazepoxide, which blocks serotonin turnover, increased food intake; and fluoxetine, a serotonin agonist, decreased food intake. Administration of combinations of the two drugs showed an antagonistic dose-dependent relationship, implicating a satiety or hunger mechanisms which is mediated by serotonin.