Nosocomial infection and bacterial spectrum in chronic uremic patients.

OBJECTIVE To investigate the site of the nosocomial infection,risk factors,and the distribution and drug resistance of bacteria in order to improve prognosis in uremic patients and facilitate the effective prevention and rational use of medicines.METHODS A retrospective analysis of 83 uremic cases with nosocomial infection in our hospital from Jan 2000 to Dec 2008 was conducted.RESULTS The nosocomial infection rate in uremic patients was 10.6%.Among them the respiratory tract infection was the first(44 cases,53.0%),then the urinary tract infection(21 cases,25.3%),gastrointestinal tract infection(6 cases,7.2%),intravenous catheterization infection(5 cases,6.0%),peritonitis(4 cases,4.8%),sepsis(2 cases,2.4%),and skin and soft tissue infection(1 case,1.2%).Bacteria were predominantly Gram-negatives,and the resistance rate was high.CONCLUSION The antibiotic resistance of nosocomial infection in uremic patients is high.We should strengthen the bacteria cultivation and drug sensitivity monitoring in clinic,choose the correct and effective antibiotic early to reduce mortality and superinfection.