ACYP2 polymorphisms are associated with the risk of liver cancer in a Han Chinese population

// Zhong Chen 1 , Yu Sun 2 , Zhenxiong Xu 2 , Junnv Xu 3 , Jingjie Li 4 , Mengdan Yan 4 , Jing Li 4 , Tianbo Jin 4, 5 and Haifeng Lin 3 1 Department of Thoracic Surgery, Second People’s Hospital of Hainan Province, Hainan, 572200, China 2 Department of General Surgery, Second People’s Hospital of Hainan Province, Hainan, 572200, China 3 Department of Internal Medicine-Oncology, Agricultural Reclamation General Hospital of Hainan Province, Hainan, 570311, China 4 Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, School of Life Sciences, Northwest University, Shaanxi, 710069, China 5 Xi’an Tiangen Precision Medical Institute, Shaanxi, 710075, China Correspondence to: Haifeng Lin, email: 13322060949@163.com Keywords: ACYP2, polymorphism, liver cancer, case-control, Han Chinese population Received: October 24, 2016      Accepted: April 05, 2017      Published: June 19, 2017 ABSTRACT We explored the association between single nucleotide polymorphisms (SNPs) in ACYP2 and liver cancer risk. Thirteen SNPs were genotyped in 473 cases and 564 controls. Genetic model, linkage disequilibrium, and haplotype analyses were performed to evaluate the association between ACPY2 SNPs and liver cancer risk. We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07−1.52, P = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02−2.1, P = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09−1.54, P = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09−1.55, P = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07−1.82, P = 0.014) were associated with an increased risk of liver cancer. In contrast, rs1682111 (A allele: OR = 0.77, 95% CI: 0.640−0.94, P = 0.007; AT vs. TT: OR = 0.69, 95% CI: 0.53−0.91, P = 0.007), rs843720 (additive model: OR = 0.82, 95% CI: 0.68−1.00, P = 0.049), ATATCGCC and CG haplotypes (OR = 0.76, 95% CI: 0.62−0.92, P = 0.006; OR = 0.78, 95% CI: 0.65−0.93, P = 0.006, respectively) were significantly decreased liver cancer risk. Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.