Enhancing CD8 T-cell memory by modulating fatty acid metabolism
2009
On antigen stimulation, CD8 T cells undergo a developmental program characterized by expansion and then contraction of antigen-specific effector (TE) populations, followed by the persistence of long-lived memory (TM) cells. During this transition, CD8 T cells are now shown to switch from glucose metabolism to fatty acid metabolism by a TRAF6-dependent mechanism.
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