Derivation of Normal Limits of Left Ventricular Ejection Fraction and Volume Measurements for the DSPECT Camera

1634 Background: Differences in spatial resolution and image filtering between the solid-state DSPECT and traditional Anger SPECT (A-SPECT) cameras are likely to result in differences in LV measurements. However, DSPECT- specific normal values have not been systematically derived. We used healthy organ-donor subjects from our high-volume solid organ transplant center for derivation of normal values. Methods: Subjects were 85 consecutive kidney or liver donors who underwent single day rest (5 mCi)- stress (15mCi) Tc-99m sestamibi gated SPECT myocardial perfusion imaging (MPI) on the DSPECT for pre-operative evaluation. Exclusion criteria included any cardiac disease or medications. LV measurements were made on the post-stress supine stress images using QGS®. Results: Of 88 subjects(mean age 54.5±15.2 and 36% men), mean EF for women and men were 76.7±15.9% and 69.2±14.3%, respectively. Mean end-diastolic volume for women and men were 66.5±35.74 ml and 102.1±52.3 ml(indexed 38.2±19.1 ml/m2 and 49.4±26.1 ml/m2), respectively. Mean LV wall volume for women and men were 96.7±28.0 mland 118.5±33.5 ml (indexed 55.6±14.5 ml/m2 and 57.3±17.3 ml/m2), respectively. Conclusion: We report DSPECT-specific LV measurements from normal subjects from which limits of normality can be derived for clinic use. Organ-donors who undergo pre-operative MPI are a suitable cohort for the derivation of normal values.