Acute Toxicity of Acetamiprid in Rats

The pathology of acute acetamiprid toxicity in female wistar rats in reported. The approximate lethal dose (ALD) by oral route was found to be 506 mgkg−1 body weight. The toxicity signs were respiratory distress, hyperaesthesia, extensive tremors and terminal clonic convulsion, coma and death. At necropsy, severe haemorrhages in lungs and mild congestion in liver were noticed. Microscopically, congestion, haemorrhages and necrosis were found in liver, lungs, spleen and heart.