Inspiratory flow rates and volumes with the Aerolizer dry powder inhaler in asthmatic children and adults

Objective: To assess the peak inspiratory flow rate (PIFR) and forced inspiratory vital capacity (FIVC) through the formoterol (Foradil) Aerolizer* in patients with mild, moderate and severe asthma. * Foradil and Aerolizer are trade names of Novartis AG, Basel, SwitzerlandResearch design and methods: PIFR and FIVC were assessed in 33 adults and 32 children using a spirometer alone (baseline), a spirometer with an adaptor, and a spirometer with an adaptor and the Aerolizer inhaler (placebo loaded).Results: Of adult patients using the Aerolizer inhaler, 73% had PIFR values of >100l/min and 91% had values of >60l/min. PIFR in adults was reduced from a mean baseline of 283l/min to 118l/min through the loaded Aerolizer inhaler. Similarly, 75% of children using the Aerolizer inhaler had PIFR values >80l/min and 91% had values of >60l/min. The mean PIFR in children was reduced from a baseline of 154l/min to 100l/min through the loaded Aerolizer inhaler. Only small mean decreases from baseline were observed in FI...