Biocompatible iron(III) carboxylate Metal-Organic Frameworks as promising RNA nanocarriers

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal–organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.