Development of a triple impinging jet mixer for continuous antisolvent crystallization of acetylsalicylic acid reaction mixture

Abstract This study aims to develop a continuous antisolvent crystallization technique using a novel non-submerged triple impinging jet mixer for multiple feeding volume ratios to perform the direct procession of a flow acetylsalicylic acid (ASA) reaction mixture. The impinging jet mixer was supplemented by an overflow mixed suspension mixed product removal (MSMPR) crystallizer to provide a longer aging period for the crystals. The effect of temperature, residence time, and antisolvent to ASA solution ratio on product purity, yield, productivity, crystal size, and crystal size distribution was examined applying a 23 two-level full factorial experimental design. It was found that due to the intensive initial mixing achieved with triple impinging jet significantly smaller crystal size (