Tumor burden score predicts tumor recurrence of non-functional pancreatic neuroendocrine tumors after curative resection

Abstract Background To investigate the feasibility of Tumor Burden Score (TBS) to predict tumor recurrence following curative-intent resection of non-functional pancreatic neuroendocrine tumors (NF-pNETs). Method The TBS cut-off values were determined by a statistical tool, X-tile. The influence of TBS on recurrence-free survival (RFS) was examined. Results Among 842 NF-pNETs patients, there was an incremental worsening of RFS as the TBS increased (5-year RFS, low, medium, and high TBS: 92.0%, 73.3%, and 59.3%, respectively; P  Conclusions TBS was strongly associated with risk of recurrence and outperformed both tumor size and number alone.