Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-κB, ERK 1/2 and toll-like receptor pathways.

Xinhui Su,Qiang Chen,Wenbo Chen,Tenghui Chen,Wenjiao Li,Yang Li,Xiaofeng Dou,Yafei Zhang,Yuemao Shen,Hua Wu,Chundong Yu

Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-κB, ERK 1/2 and toll-like receptor pathways.

2014

Xinhui Su
Qiang Chen
Wenbo Chen
Tenghui Chen
Wenjiao Li
Yang Li
Xiaofeng Dou
Yafei Zhang
Yuemao Shen
Hua Wu
Chundong Yu

National Natural Science Foundation of China [81071182]; Medical Innovation Foundation of Fujian, China [2009-CXB-46]; Natural Science Foundation of Fujian Province of China [2010D015]; Youth Foundation of Health Department of Fujian Province [2010-2-84]

Keywords:

Mitogen-activated protein kinase
Toll-like receptor
Microglia
Biochemistry
MAPK/ERK pathway
Lipopolysaccharide
Proinflammatory cytokine
Immunology
NF-κB
Apoptosis
Biology

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