Expression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients

Usama Khamis Hussein,Ho Sung Park,Jun Sang Bae,Kyoung Min Kim,Yun-Jo Chong,Chan-Young Kim,Keun Sang Kwon,Myoung-Ja Chung,Ho Lee,Myoung Jae Kang,Woo Sung Moon,Kyu Yun Jang

Expression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients

2018

Usama Khamis Hussein
Ho Sung Park
Jun Sang Bae
Kyoung Min Kim
Yun-Jo Chong
Chan-Young Kim
Keun Sang Kwon
Myoung-Ja Chung
Ho Lee
Myoung Jae Kang
Woo Sung Moon
Kyu Yun Jang

Background Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and inducing the phosphorylation of H2AX (γH2AX) in response to DNA damage.

Keywords:

Carcinoma
Cancer research
Phosphorylation
Medicine
Intracellular
DNA damage
Protein tyrosine phosphatase
Oxidative stress
Carcinogenesis
Oxidative phosphorylation
Stomach
Immunohistochemistry

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