Gamma-delta T lymphocytes in Glioblastoma patients

Gamma-delta (??) T cells are important effector lymphocytes of innate immunity with proven anti-tumour reactivity against aggressive glioblastoma brain tumour (GBM) (Knight et al., PLoS One 2013). Therapeutic approaches to GBM have had limited success particularly due to the protective brain barrier and the tumour immunosuppressive microenvironment. The GBM-infiltrating ?? T lymphocytes (TILs) have not been extensively investigated.