Impact of Antimalarial Adherence on Mortality among Patients with Newly Diagnosed Systemic Lupus Erythematosus: A Population‐based Cohort Study

OBJECTIVE To assess the association of antimalarials (AM) adherence with premature mortality among incident systemic lupus erythematosus (SLE) patients. METHODS All patients with incident SLE and incident AM use in British Columbia, Canada, between January 1997 and March 2015 were identified using the provincial administrative databases. Follow-up started on the first day of having both SLE and AM. The outcome was all-cause mortality. An adherence measure, proportion of days covered (PDC), was calculated and categorized as adherent (PDC≥0.90), non-adherent (0

Keywords:

• Lower risk
• Proportional hazards model
• Internal medicine
• Hazard ratio
• newly diagnosed
• Confounding
• systemic lupus
• Inverse probability weighting
• Medicine
• population based cohort

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