Influence of neighbourhood-level crowding on sleep-disordered breathing severity: mediation by body size

Summary Neighbourhood-level crowding, a measure of the percentage of households with more than one person per room, may impact the severity of sleep-disordered breathing. This study examined the association of neighbourhood-level crowding with apnoea–hypopnoea index in a large clinical sample of diverse adults with sleep-disordered breathing. Sleep-disordered breathing severity was quantified as the apnoea–hypopnoea index calculated from overnight polysomnogram; analyses were restricted to those with apnoea–hypopnoea index ≥5. Neighbourhood-level crowding was defined using 2000 US Census tract data as percentage of households in a census tract with >1 person per room. Multivariable linear mixed models were fit to examine the associations between the percentage of neighbourhood-level crowding and apnoea–hypopnoea index, and a causal mediation analysis was conducted to determine if body mass index acted as a mediator between neighbourhood-level crowding and apnoea–hypopnoea index. Among 1789 patients (43% African American; 68% male; 80% obese), the mean apnoea–hypopnoea index was 29.0 ± 25.3. After adjusting for race, age, marital status and gender, neighbourhood-level crowding was associated with apnoea–hypopnoea index; for every one-unit increase in percentage of neighbourhood-level crowding mean, the apnoea–hypopnoea index increased by 0.40 ± 0.20 (P = 0.04). There was a statistically significant indirect effect of neighbourhood-level crowding through body mass index on the apnoea–hypopnoea index (P < 0.001). Neighbourhood-level crowding is associated with severity of sleep-disordered breathing. Body mass index partially mediated the association between neighbourhood-level crowding and sleep-disordered breathing. Investigating prevalent neighbourhood conditions impacting breathing in urban settings may be promising.