Abstract 13992: The Clinical Significance of Diastolic Late Mitral Annular Velocity in Heart Failure With Preserved Left Ventricular Ejection Fraction

Background: Left atrial (LA) structure are altered in the majority of HF with preserved LVEF (HFpEF) patients. Because diastolic late mitral annular velocity (a’) measured by transthoracic echocardiography (TTE) is reported to represent the severity of LA remodeling, we investigated clinical significance of a’ in HFpEF. Methods: We enrolled 422 consecutive HFpEF patients (sinus rhythm [SR]: n=337 [79.9%], atrial fibrillation [AF] rhythm: n=85 [20.1%]), admitted to Kumamoto University Hospital from 2006 to 2013, and performed TTE at stable condition after optimal therapy for HF. In patients with SR at the time of TTE, a’ values as an average of tissue Doppler velocities measured at septal and lateral mitral annuli. All HFpEF patients were followed until occurrence of cardiovascular events. Results: In HFpEF patients with SR, a’ had a weak but significant negative correlations with B-type natriuretic peptide (BNP) (r=0.22, p Conclusion: Estimation of a’ value is a non-invasive and useful method for risk stratification in patients with HFpEF.