Is the acetylcholine-regulated inwardly rectifying potassium current a viable antiarrhythmic target? Translational discrepancies of AZD2927 and A7071 in dogs and humans.

Håkan Walfridsson,Ole-Gunnar Anfinsen,Anders Berggren,Lars Frison,Steen M. Jensen,Gunilla Linhardt,Ann-Christin Nordkam,Monika Sundqvist,Leif Carlsson

Is the acetylcholine-regulated inwardly rectifying potassium current a viable antiarrhythmic target? Translational discrepancies of AZD2927 and A7071 in dogs and humans.

2015

Håkan Walfridsson
Ole-Gunnar Anfinsen
Anders Berggren
Lars Frison
Steen M. Jensen
Gunilla Linhardt
Ann-Christin Nordkam
Monika Sundqvist
Leif Carlsson

AIMS: We aimed at examining the acetylcholine-dependent inward-rectifier current (IKAch) as a target for the management of atrial fibrillation (AF).METHODS AND RESULTS: The investigative agents AZD ...

Keywords:

Acetylcholine
Anesthesia
Cardiology
Potassium
Internal medicine
Medicine
Management of atrial fibrillation
Electrophysiology
Ion channel
potassium current

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