Morphological changes in the tissues of the experimental model of hemangioma with concurrent medication of β-blockers and interstitial introduction of the Kenalog preparation.

Relevance. Hemangiomas are the most common variety among tumors of the skin and soft tissues in children. The number of patients with this pathology is currently increasing. There are many methods to therapy hemangiomas in children. Currently, such drugs as Propranolol and Kenalog are widely used in the treatment of this pathology. The aim is to study the effect of β-blockers and the preparation of Kenalog on the tissues of the experimental model of hemangioma at joint administrated. Materials and methods. 20 live chickens were used for the experimental study. The histological structure of the vascular or capillary zone of the crest of the chicken resembles the human hemangioma. All chickens were divided into 4 groups of 5 individuals. Observing the general condition of chickens, macroscopic and histological examination of the crest of the hens were carried out. Results and conclusions. All the chickens from the experimental group had died presumably by the 15th day because of massive vascular thrombosis. The joint administrated of β-blockers and the Kenalog product is not recommended because of the possibility of thrombus formation and a high probability of death.