EP242 Is the depth of cone related to the endocervical glandular involvement in patients who underwent loop electrosurgical excision procedure or cold knife conization

Introduction/Background The aim of our study was to determine whether endocervical glandular involvement after excisional procedures is related to the depth of the removed conization material. Methodology Between April 2016 and December 2019, patients who underwent colposcopy and excisional procedures in the department of gynecologic oncology were investigated retrospectively. Patients with multiple pathology specimen pieces and the patients whose cone depth was not measured were excluded from the study. Age, endocervical curettage (ECC) results during colposcopy, type of excisional procedure (LEEP or CKC), degree of dysplasia in cone material, endocervical glandular involvement and cone depth were evaluated from medical records. Results Four hundred thirty patients included in the study. The mean age was 41.3 years. Sixty-one patients who underwent LEEP and 369 patients who underwent conization were evaluated. Three hundred fifteen (73.2%) patients had no glandular involvement, while 115 patients (26.7%) had glandular involvement. In the analyses, cone depth and endocervical glandular involvement showed statistically significant differences between the patients with LEEP and CKC (p=0,049). Mean cone depth in LEEP group and CKC group were 7.9 mm and 14.5 mm, respectively (p Conclusion The depth of cone was found to be unrelated to determine endocervical glandular involvement. Although LEEP group has lees cone depth and less glandular involvement, the predictive factors for glandular involvement should be determined in prospective randomized trials. Disclosure Nothing to disclose.