Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers

Nathalie Rioux,Amy Kim,Darrell Nix,Todd Bowser,Markus Warmuth,P.G.R. Smith,Joanne Schindler

Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers

2019

Nathalie Rioux
Amy Kim
Darrell Nix
Todd Bowser
Markus Warmuth
P.G.R. Smith
Joanne Schindler

Purpose This Phase I study estimated the effect of a high-fat meal on the pharmacokinetics (PK) of H3B-6527, a covalent inhibitor of the fibroblast growth factor receptor (FGFR) 4 in clinical development for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Keywords:

Fibroblast growth factor receptor
Pharmacology
Hepatocellular carcinoma
Meal
Fibroblast growth factor receptor 4
Bioavailability
Intrahepatic Cholangiocarcinoma
Medicine
FOOD EFFECT
Pharmacokinetics
Crossover study
Cmax
Confidence interval
Liquid chromatography–mass spectrometry
Endocrinology
Internal medicine
Tolerability

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