Toxic but tasty – temporal dynamics and network architecture of heme‐responsive two‐component signaling in Corynebacterium glutamicum

Heme is an essential cofactor for almost all bacterial species but may cause severe toxicity upon elevated levels. In this study, we present a combined experimental and theoretical approach analyzing the temporal dynamics of heme detoxification and utilization in Corynebacterium glutamicum, which are orchestrated by the two two‐component systems ChrSA and HrrSA. These systems represent an interesting example of network evolution optimizing the cellular response to a multifaceted stimulus. Open in a separate window