Mandibular three-dimensional finite element analysis for a patient with an aggressive form of craniofacial fibrous dysplasia

The longitudinal change in mandibular volume and configuration was quantitatively evaluated in a patient with craniofacial fibrous dysplasia (FD). The influence of mechanical stress on the enlargement that is characteristic of FD was verified via finite element analysis (FEA). The patient was a 38-year-old man diagnosed with craniofacial FD in the mandible. He underwent surgical reduction of FD, but the lesion continued to grow and caused facial asymmetry and masticatory disturbance because of missing teeth. An occlusal overlay removable partial denture was constructed for his lower jaw. Computed tomography (CT) images were acquired 4 times in 10 years, and 3-dimensional (3-D) models were reconstructed from these data. The 3-D models were analyzed volumetrically and morphologically and used for FEA. The FD lesion in the mandible enlarged nonuniformly and had site specificity. From the results of FEA, it is suggested that compression stress induced by the occlusal force through the denture may have influenced the direction of enlargement in FD.