Vascular Lesions Causing Hypertension in Neurofibromatosis

NEUROFIBROMATOSIS is a congenital and hereditary disorder involving ectodermal, neuroectodermal and mesodermal tissue. Cafe-au-lait spots, cutaneous neurofibromas, tumors of the central and peripheral nervous systems, skeletal changes of scoliosis, orbital-wall defects, pseudarthrosis and gigantism are well known manifestations. The occurrence of vascular lesions is less well known but has been described by a number of authors.1 2 3 4 These vascular changes are said to predominate in the kidneys, endocrine glands, heart and gastrointestinal tract, and may lead to arterial stenosis or obliteration of the arterial lumen. When these vascular lesions of neurofibromatosis involve the abdominal aorta or the renal arteries systemic arterial . . .